Medical Anthropology Paper-Tay Sachs Disease Essay Example

Medical Anthropology Paper Medical Anthropology Paper-Tay Sachs Disease Paper Medical Anthropology Paper-Tay Sachs Disease Paper A normal infant has the ability to develop healthy motor functions due to the synthesis of certain enzymes vital for clearing harmful materials that can interrupt the growth process. However, babies that inherit the gene coding for Tay-Sachs disease experience motor function disorders. Tay-Sachs disease is a rare genetic disorder inherited by individuals that causes the degradation of their central nervous system. This condition is not treatable. Moreover, it progresses continuously from infancy until early childhood, a point where the patient fails to survive. The disease occurs within a defined population, commonly found among eastern European Ashkenazi Jews. The said disorder results from genetic mutations whose effects are manifested from infancy and are highly fatal for affected babies. In addition, it is acquired through genetic inheritance and is detectable prior the childs birth (Lowden 575). The disease is due to a mutation at chromosome number 15 which results in a dysfunction of the lysosomal enzyme acid hydrolase. Deficiency of Beta Hexosaminidase A is characteristic among afflicted patients. This enzymatic absence can be attributed to the occurrence of a founder effect, which accounts for the unusually high frequency of an allele that is an identical copy carried by the individual who founded the population (Slatkin 282). Currently, there are neither treatments nor drugs that would cure Tay-Sachs disease. However, studies have shown that it is possible to prevent the manifestation of Tay-Sachs among potential patients. This leads to the interests of researchers in screening for the probability of passing this disease from heterozygous parents to offspring (Lowden 575). History The disease derived its name from a British ophthalmologist named Warren Tay (1843-1927) and an American neurologist named Bernard Sachs (1858-1944). Tay first provided the characteristic description of retinal cherry-red spot in the eyes while Sachs provided the earliest descriptions of the cellular modifications occurring among afflicted patients. It was also Sachs who first concluded that this disorder is acquired through inheritance from parental genes through studies conducted among numerous patients. His research revealed that this disease notably occurs among Ashkenazi Jews of Eastern European origin (www. ntsad. org). In the year 1900, Sachs collaborated with Dr. Isadore Strauss, who then served as Mount Sinais director of pathology. Their concerted work provided additional descriptions of Tay-Sachs patients, which included observations on the diseases neuropathology. By the middle part of the 1920s decade, Mount Sinai Hospital had finally established a laboratory for neuropathological studies headed by Dr. Joseph Globus. Through this program, scientists were able to identify that autonomic neurons in bowel mucosa are involved. This was used as a diagnostic test, as direct enzymatic assays were not yet discovered. These observations were highly used in determining Tay-Sachs cases and other associated genetic disorder â€Å"through the use of morphological studies of rectal biopsies† (Desnick and Kaback 18). Succeeding years relatively added few descriptions on the morphology of Tay-Sachs disease. But with the onset of the electron microscope during the 1960s, Terry and Korey were able to find numerous bodies bounded by membranes in the cytoplasm of neurons of patients with Tay-Sachs disease. The researchers used a formalin fixed brain specimen, where the tissues were poorly preserved. But the granular bodies that they detected were consistent with brain tissues that were not previously fixed in formalin but immediately placed in a frozen state. In 1963, Terry collaborated with a researcher named Weiss and their studies revealed that the disease is characterized by these granular bodies in the neuronal cytoplasm. Their research team discovered the nature of the lipids that accumulate within neurons, microglial cells, and pericytes. According to their biochemical findings, these deposits possess a ganglioside nature (Desnick and Kaback, 22). Also during the 1960s, an enzyme assay test was developed by Kaback in order to screen heterozygous individuals carrying the allele for Tay-Sachs disease. This test was proven reliable, as it statistically demonstrates low percentage of errors and false positives. The test historically started the determination of potential genetic diseases among offspring. This is essential in preventing diseases and eventually leading to close eradication of the disease among Ashkenazi Jews. Now, it is possible to identify whether couples are at risk in having a child afflicted with the disease (Kaback 255). These efforts of Kaback, together with his team, led to the mass screening of potential disorders among individuals. This program was carefully organized and on May of 1971, approximately 18, 000 adults with Ashkenazi Jewish descent volunteered to be screened for possible heterozygosity. The said screening proved efficient and accurate in determining populations which are potentially at risk. In addition, the screening lasted and from 1969 until 1998, a total of 48,864 heterozygotes were already screened (Kaback 256). Clinical Description The degree of severity of Tay-Sachs manifestation can vary depending on the type of disease. An autosomal recessive disease, Tay-Sachs can cause â€Å"paralysis, dementia, and early death to a chronic adult form† (Genes and Disease 23). These adults afflicted by Tay-Sachs typically manifest psychosis and even neural dysfunction (Genes and Disease 23). Other manifestations of this disease include blindness and deafness early in life. Babies born with Tay-Sachs disease may develop normally during their first 3-6 months, but would eventually deteriorate mentally. They experience delay in mental progression as they experience loss of motor abilities. By the end of their first 12 months, patients rapidly regress mentally and physically. They are exposed to complications in swallowing, as well as in chest, and lung functions (Hauser 2171). Symptoms of this disease include cherry-red macular spots (see Figure 1), or a highly pronounced macular fovea centralis, and an enlarged heart. Babies with this genetic disorder experience disabled motor skills as they could poorly manage to control their heads, fail to crawl, sit and develop visual attention. They also characteristically assume a position that resembles those of frogs. Babies, supposedly at the stage of rapid development, lose their ability to maintain focus and eye contact, when Tay-Sachs starts to manifest. They also exhibit declining environmental interactions while gradually becoming unresponsive. They also develop inattention towards external stimuli until they reach a state that otherwise described vegetative. Hyperacusis, seizure, and macrocephaly are typical of Tay-Sachs disease (Kasper et al. 2318; lysosomallearning. com). There are three forms of Tay-Sachs disease. This includes the classic infantile, the juvenile form, and the adult form. Infants afflicted with Tay-Sachs do not produce Hexosaminidase A, while adults with this disease produce minimal enzymatic levels. Babies born with this disease experience both paralysis and muscle atrophy by six months of age and do not survive longer than five years. Most common ages when children manifest juvenile Tay-Sachs disease are those from 2 to 10 years old. The symptoms of patients are comparable to those with classic infantile form, but with a slower process. They develop dysarthria or speech problems, dysphagia or swallowing complications, ataxia or imbalance, and even spasticity. Patients generally die by their 15th year of age. The effects of the adult version are relatively milder than the classic infantile form, which attributes to their late onset in life. These individuals are otherwise known to possess chronic Tay-Sachs disease. Those with the adult-onset Tay-Sachs disease usually manifest symptoms by their adolescent stage, but it is also possible that these appear during childhood. Unlike babies with Tay-Sachs disease, adults with this disease do not experience blindness or deafness. Although the motor abilities are not completely degenerated, these individuals continuously experience mental weaknesses, including comprehension and memory problems. But different cases present various severity, as some can exhibit â€Å"slurred speech, muscle weakness, muscle cramps, tremors, unsteady gait and sometimes mental illness† (marchofdimes. com). Persons afflicted vary in life expectancy and some may not even to demonstrate the disease. Doctors determining the presence of this disease in individuals must consider investigating the following. Erythrocyte content of both carriers and afflicted individuals are considerably lower concentrations of sphingomyelin. Also, using the enzyme assay, serum or other cell cultures without or with less activities of Hexosaminidase A are a significant consideration. If these tests demonstrate abnormalities, then a DNA analysis must immediately be conducted. This is highly beneficial in determining other members of the family that are heterozygotes for this disorder. This has important implications in child-bearing options of couples and in diagnosing the disease prior a child’s birth. MRI are also commonly used in searching for cerebellar atrophy while electromyelogram is also used in detecting denervation and reinnvervation in individuals with adult-onset of this disease (Tidy; Zaroff 2283). Pathogenesis The most essential organelle involved in Tay-Sachs disease is the lysosome. The biogenesis of this organelle is comprised of different steps synthesizing the following: lysosomal hydrolases, membrane constitutive proteins, and new membranes. The formation of lysosomes is initiated by the fusion of trans-golgi network and late endosomes. With the acidification of vesicles in progression, trans-Golgi network vesicles develop towards maturity. This process creates a gradient that promotes the facilitation of ligand and receptor dissociation. This is highly dependent on the pH levels of the system. Here, lysosomal hydrolases are also activated (Kasper 2318). Any form of interference or abnormalities in these steps of lysosomal biogenesis could result to enzymatic impairment and lead to lysosomal storage disorder. â€Å"Following leader sequence clipping, complex oligosaccharide modification occur during transit through the Golgi, including the mannose-6-phosphate modification of high-mannose oligosaccharide chains of many soluble lysosomal hydrolases† (Kasper 2318). Using various kinds of signals, the lysosomal integral or associated membrane proteins are sorted to the membrane or interior of the lysosome. Concurrently, other processes occur such as phosphorylation, sulfation, proteolytic processing, and macromolecular assembly of heteromers. These are all very crucial steps to ensure the normal functioning of enzymes. Defects of these processes could lead to multiple enzyme or protein deficiencies (Kasper 2318). These mentioned steps are all common for lysosomal storage diseases. But the final pathway is when particular macromolecules, under normal circumstances have high flux of these substrates, within tissues and cells accumulate. When enzymatic deficiency occurs, the most common and major cause are point mutations or genetic rearrangements at a locus that encodes a single lysosomal hydrolase (Kasper 2318). These consequently result in diseases that are passed on from one generation to another. An example of lysosomal storage disorder is the Tay-Sachs disease. This complication is considered an autosomal recessive disorder that is acquired through genetic inheritance. A lysosomal acid hydrolase, ? -N-Hexosaminidase A is a heterodimer composed of alpha and beta subunits. A point mutation occurring at the ? -chain subunit results in an enzymatic deficiency of ? -N-Hexosaminidase A (Myerowitz 3955). The disorders that arise from the mutation of the alpha subunit cause the dysfunction of ? -N-Hexosaminidase A activity. This also includes the abolition of the alpha and beta isozyme activities through the action of the remaining beta subunit (see Figure 2). Tay-Sachs disease is described as one of the earliest versions of human genetic sphingolipidoses where patients suffer from the accumulation of GM2-monosialoganglioside in neurons due to the mentioned ? -N-Hexosaminidase A deficiency (Ohno and Suzuki 18563). The comparison between a healthy neuron and a neuron affected by Tay-Sachs disease is illustrated in Figure 3. The abnormality of the ? -subunit can be attributed to the major deletion found at the 5 end of the gene coding for ? -N-Hexosaminidase A ? chain. It was also discovered that in the coding sequences of ? subunits in relatively mature stages, point mutations occur that consequently result to the synthesis of unique enzymes of GM2-gangliosidosis. In cases of Ashkenazi Jews, patients were observed to possess splicing defects located at the 5 end, where intron 12 is usually donated. This splicing complication was described by employing methods such as cloning, genomic sequencing, and identification of abnormal cDNAs (Ohno and Suzuki 18563). Tay-Sachs is actually a â€Å"group of disorders† (Myerowitz 3955) with varying degree of severity and biochemical parameters. Severity ranges from mild to fatal while the parameters include â€Å"residual enzyme activity, immunoprecipitable ? -chain polypeptide, and detectable ? -chain mRNA† (Myerowitz 3955). These mentioned variations are part of differential ? -chain genetic lesions. In the case of Ashkenazi Jews, this disease has a single clinical course that leads to early childhood death and same biochemical profiles. Scientists hypothesized that the severe form of this disease is caused by a single mutation (Myerowitz 3955). It has been established that Tay-Sachs is the result of accumulation of Ganglioside GM2 due to the cells inability to degrade these granular bodies. In the absence of GM2 activator protein, â€Å" the GalNAc and NeuAc in GM2 are refractory to hexosaminidase A and sialidase respectively† (Li et al. 10014). In the study, it was found that in analyzing the conformatino of these GM2, a rigid and compact structure of the oligosaccharide head group was revealed. This is concluded to be the factor responsible for the resistance of GM2 from degradation or enzymatic hydrolysis (Li et al. 10014). All these abnormal processes are primarily attributable to mutations that occur on chromosome 15. Mutations include insertions and deletions of different base pairs, splice site mutations, point mutations, and other forms. With every modification resulting from mutation processes result in the alteration of the protein or enzymatic product, which causes the inhibition of its function. One of the most commonly observed and noted mutations are those of the Ashkenazi Jews where four base pairs are inserted in exon 11. The result is the classic infantile Tay-Sachs disease that can also be found in other ethnicities (Ohno 18563). Etiology This disease is commonly passed on from carrier parents to their offspring. Children that possess both alleles for Tay-Sachs manifest and suffer from the disease. The human body is composed of 23 pairs of chromosomes, therefore 46 chromosomes in total. These chromosomes contain genetic instructions that always come in pairs, from both maternal and paternal inheritance. But when these genes experience alterations or any form of modification, a mutation occurs and the gene loses its normal functions. Since each individual has two chromosomes, those with only one copy of the dysfunctional gene will be able to continue to function correctly as the normal gene would compensate for the impairment of the other. But if an individual acquires two recessive alleles, the individual will manifest the symptoms characteristic of the disease (Branda et al. 174; www. dnadirect. com). In cases when both parents are heterozygous for the Tay-Sachs gene, there is a 25% probability of passing the disease to the offspring, while a 50% probability of bearing a carrier individual and a 25% chance of a phenotypically and genotypically normal child (see Figure 4). In situations when only one parent is a carrier, there are 0% chances of having an afflicted child. However, they still have a 50% risk of having an offspring carrying the gene for Tay-Sachs (Branda et al. 174; www. dnadirect. com). Epidemiology Tay-Sachs disease is one of the most renowned genetic disorders associated with a certain population. This is a metabolic disorder typically acquired through genetic inheritance and occurs most frequently among Ashkenazi Jews of Eastern Europe. However, the disease is not confined within this group as it is also found among French Canadians that inhabit the South-eastern portion of Quebec and among Cajuns that live in the South-western part of Louisiana (Genes and Disease 23). One of the causes that scientists propose on the emergence of this disease is founder effect. Founder effect is a potential cause for a high frequency allele within a population in isolation. This is the case if the allele selectively remains in neutrality and if it has identical copies of the original carrier that founded the subpopulation. This is also applicable in conditions where an allele simply arose by later mutating (Slatkin 282). In explaining the phenomenon of the occurrence of high frequency alleles, experts have always employed this founder effects hypothesis. Most disease associated alleles are likely to be non-neutral. However, even alleles with mild deleterious effects could gain high levels of frequency due to founder effects. Today, another explanation is widely accepted in the scientific community in accounting for Tay-Sachs disease. This is the heterozygote advantage. This hypothesis is basically supported by the fact that most disease associated with alleles result from sphingolipid storage dysfunction. This outcome is not commonly observed in the general population. These two hypotheses were highly acknowledged prior the 1990s. But until recently, the heterozygote advantage was questioned and the founder effect has gained a relatively greater acceptance. This is due to several research studies conducted that argued in favour of founder effects as the actual cause of lipid storage diseases in the Ashkenazi Jewish population. The heterozygote advantage is unlikely as some non-lipid storage diseases (NLSDs) are due to dominant instead of recessive alleles and that these NLSDs do not benefit from the presence of disease associated alleles (Slatkin 282). The study on the debate between genetic drift and selection were further investigated by Risch et al. (p. 812). It has been established that Ashkenazi Jews have higher tendencies to acquire lysosomal storage diseases (LSDs), and in this study, four were found to occur at high frequencies. It was suggested that this condition is a result of having natural selection, otherwise termed as carrier advantage, as an impetus. The researchers compared the LSDs and NLSDs in terms of their levels of mutations, allelic frequency distribution, and mutation coalescence dates. It was found that there were no differences in the distribution nor any regular distribuion patterns were observed between LSDs and NLSDs occurring in different geographic areas. But the scientists discovered a more interesting concentration of two particular Tay-Sachs mutations in central and eastern Europe. Such an observation is an indication that genetic drift or the founder effect is the driving force that affected the population. It is the primary determinant of the genetic mutations that occur in Ashkenazi Jews (Risch et al. 812). Treatment and Screening An effective treatment or cure is currently not available for Tay-Sachs disease. Due to this, scientists are exploring on various possibilities that would enable them to formulate the appropriate treatment and management of this disease. Through intensive research projects using therapeutic approaches and clinical trials, experts have discovered a potential cure. This is by employing enzyme replacement therapy in order to compensate for the deficiency of ? -N-Hexosaminidase A absent among afflicted infants and even among adult patients. But this proposal entails several complications as it can affect the brain neurons that receive protection from the blood-brain barrier. Other current studies include gene therapy, pharmacological chaperone therapy, and neural stem cell therapy. Another alternative research is conducted on stem cell transplantation employing the blood of umbilical cord, but all these mentioned potential cure are still under the process of scientific research (www. nstad. org). These stem cell research studies investigate the potential of transplanting bone marrow in treating classic Tay-Sachs disease. These stem cells are immature cells that can differentiate into any form of cell (see Figure 5). In this case, scientists are seeking to produce blood cells from these stem cells either from a bone marrow donor or umbilical cord blood. But this remains unsuccessful in causing the reversal of brain damage that is fatal for afflicted patients. Drug options are also being explores by medical experts, which includes the miglustat drug. This has the ability to cause fatty build up reduction in the brain cells of Tay-Sachs disease patients (Escolar et al. , 2; Bembi 278; marchofdimes. com). The enzyme replacement therapy proposal is basically applicable to most lysosomal storage disorders. The objective is to perform an enzymatic replacement, a procedure comparable to that of injecting insulin to diabetics. The problem in this procedure is that HEXA enzymes are relatively too large to penetrate the blood-brain barrier. This causes the development of blood vessel junctions in the brain, which leads to neuronal cell damage. Alternate pathways were also tested such as injecting the enzyme to the cerebrospinal fluid, but this treatment is still left ineffective (www. freepatentsonline. com). As mentioned in the historical background of this disease, screening for potential carriers is very essential in preventing the manifestation of Tay-Sachs. This is very vital for populations such as Ashkenazi Jews, French Canadians, Louisiana Cajuns, and even Pennsylvania Dutch. This procedure is recommended to be conducted prior conceiving an offspring. But even after the end of an individuals childbearing years, it is still important to be screened for ones status as a carrier as it would make a tremendous difference in the lives of immediate family and close relatives (www. nstad. org). Prenatal tests are currently available such as amniocentesis and chorionic villus sampling. These tests determine the existence of the disease prior a childs birth. Typically conducted between the 15th and 20th week of pregnancy, women can choose amniocentesis where a needle is inserted to the mothers abdomen to obtain amniotic fluid samples. Fetal cells are contained within this fluid and therefore can be tested whether they possess ? -N-Hexosaminidase A. Another test usually conducted between the 10th and 12th weeks of pregnancy is CVS. This is done through the retrieval of placental cells either through tube insertion on the vagina or needle penetration through the maternal abdominal area. Again, the objective is to obtain fetal cells that would be tested for the presence of ? -N-Hexosaminidase A. If these tests reveal the absence of ? -N-Hexosaminidase A, the infant will eventually manifest the classic Tay-Sachs disease. These tests are currently being offered especially to couples who are positive for carrying the allele, and most often to those who resort to in vitro fertilization (www. marchofdimes. com). Conclusion One of the clinical considerations of this disease is that it is caused by an organelle dysfunction, particularly lysosomes. Most cells have a limited life span and therefore must be continuously replaced. Without the proper amount of lysosomal enzymes as typically attributable to a genetic disorder, the result is an abnormal accumulation of glycogen and lipids that could destroy the tissue. This case is demonstrated by Tay-Sachs disease, together with other disorders such as Gauchers disease and glycogen storage. Due to this accumulation, myelin sheaths are destroyed which would lead to the different clinical manifestations of Tay-Sachs disease. (Van de Graaff 370). The Tay-Sachs gene occurs one in every 30 Ashkenazi Jews, making almost 3% of this population as carrier of this disease. Due to lysosomal storage dysfunction, the individual becomes deficient of an enzyme called Hexosaminidase A, which codes for the metabolism of lipid molecules in cellular systems. This fatal neurodegenerative disease has an infantile form and manifests through symptoms such as macrocephaly, loss of motor skills, increased startle reaction, and a macular cherry red spot. Patients exhibiting ataxia and dementia, the juvenile-onset form of Tay-Sachs causes the death of afflicted individuals between ages 10 and 15. The adult onset of this disease is characterized by â€Å"clumsiness in childhood, progressive motor weakness in adolescence, and additional spinocerebellar, lower motor neuron symptoms, and dysarthria in adulthood† (Kasper 2318). Patients commonly demonstrate psychosis and their intelligence continuously declines. Bembi, B. â€Å"Substrate Reduction Therapy in the Infantile Form of Tay-Sachs Disease. † Neurology, 66 (2006): 278-280. Branda KJ, Tomczak J, Natowicz, MR. 2004. â€Å"Heterozygosity for Tay-Sachs and Sandhoff diseases in non-Jewish Americans with ancestry from Ireland, Great Britain, or Italy. † Genet Test 8 (2004):174-180 Desnick, R. , and Kaback, M. Tay-Sachs Disease. Ed. USA: Academic Press, 2001. â€Å"Tay Sachs Disease. † 29 January 2008 dnadirect. com/patients/tests/ashkenazi/tay_sachs. jsp. Escolar, Maria L. , Michele D. Poe, James M. Provenzale, Karen C. , Richards, M. D. , June Allison, R. N. , Susan Wood, P. N. P. , David A. Wenger, Daniel Pietryga, Donna Wall, Martin Champagne, Richard Morse, William Krivit and Joanne Kurtzberg, M. D. â€Å"Transplantation of Umbilical-Cord Blood in Babies with Infantile Krabbes Disease. † The New England Journal of Medicine, 352 (2005):2069-2081. â€Å"Compositions and method for treating lysosomal storage disease. † 30 January 2008 freepatentsonline. com/6066626. html â€Å"Cord Blood. † 4 February 2008 cordbloodusa. org/articles-a1-Cord_Blood. htm. â€Å"Genes and Disease. † Bethesda (MD): National Library of Medicine (US), NCBI. 29 January 2008 ncbi. nlm. nih. gov/books/bv. fcgi? rid=gnd. section. 238. Hauser SL, Longo DL, Harrison’s Principles of Internal Medicine. Ed. 14th ed. New York: McGraw-Hill; 1998; p. 2171. Kasper, D. L. , A. S. Fauci, D. L. Longo, E. Baraunwald, S. Hauser, S. L . Jameson, Harrison’s Principles of Internal Medicine 16th Ed. USA: McGraw-Hill Companies, Inc. 2005. Li, Y. , S. Li, , A. Hasegawa, H. Ishida, M. Kiso, A. Bernardi, P. Brocca, L. Raimondi, and S. Sonnino. â€Å"Structural basis for the resistance of Tay-Sachs Ganglioside GM2 to enzymatic degradation. † The Journal of Biological Chemistry, 274:10014-10018, 1999. Lowden, J. A. â€Å"Role of the physician in screening for carriers of Tay-Sachs disease. † CMA Journal 119 (1978):575-585. â€Å"Tay-Sachs Disease. † 29 January 2008 marchofdimes. com/professionals/14332_1227. asp. Myerowitz, R. â€Å"Splice junction mutation in some Ashkenzi Jews with Tay-Sachs disease. † Natl. Acad. Sci. USA, 85 (1998):3955-3959. â€Å"National Tay-Sachs and Allied Diseases Association. † 29 January 2008 ntsad. org/. National Eye Institute. 4 February 2008 nei. nih. gov/resources/eyegene/redeye. jpg Society for Neuroscience. 4 February 2008 sfn. org/SiteObjects/published/0000BDF20016F63800 FD712C3158BA55/0000BDF200000

Pigs Pork and Animal Rights - What is Wrong with Eating Pork

Pigs Pork and Animal Rights - What is Wrong with Eating Pork Approximately 100 million pigs are killed for food each year in the United States, but some people choose not to eat pork for a variety of reasons, including concerns about animals rights, the welfare of the pigs, the effects on the environment, and their own health. Pigs and Animal Rights A belief in animal rights is a belief that pigs and other sentient beings have a right to be free of human use and exploitation. Breeding, raising, killing and eating a pig violates that pigs right to be free, regardless of how well the pig is treated. While the public is becoming more aware of factory farming and demanding humanely raised and slaughtered meat, animal rights activists believe that there is no such thing as humane slaughter. From an animal rights perspective, the only solution to factory farming is veganism. Pigs and Animal Welfare Those who believe in animal welfare believe that humans can ethically use animals for our own purposes as long as the animals are treated well while they are alive and during slaughter. For factory farmed pigs, there is little argument that the pigs are treated well. Factory farming began in the 1960s, when scientists realized that agriculture was going to have to become much more efficient to feed an exploding human population. Instead of small farms raising pigs outdoors in pastures, larger farms started raising them in extreme confinement, indoors. As the U.S. Environmental Protection Agency explains: There has also been a significant change in how and where hogs are produced in the U.S. over the past 50 years. Low consumer prices, and therefore low producer prices, have resulted in larger, more efficient operations, with many smaller farms no longer able to produce pigs profitably. Pigs are cruelly abused on factory farms from the time they are little piglets. Piglets routinely have their teeth clipped, have their tails cut off and are castrated without anesthesia. After weaning, the piglets are put in crowded pens with slotted floors for the manure to fall through, into a manure pit. In these pens, they each typically have only three square feet of room. When they become too large, they are moved to new pens, also with slotted floors, where they have eight square feet of space. Because of crowding, the spread of disease is a constant problem and the entire herd of animals is given antibiotics as a precaution. When they reach their slaughter weight of 250-275 pounds, at around five to six months of age, most are sent off to slaughter while a small number of females become breeding sows. After being impregnated, sometimes by a boar and sometimes artificially, breeding sows are then confined in gestation stalls that are so tiny, the animals cannot even turn around. Gestation stalls are considered so cruel, they have been banned in several countries and in several U.S. states, but are still legal in most states. When the breeding sows fertility drops off, usually after five or six litters, she is sent off to slaughter. These practices are not only routine but legal. No federal law governs the raising of farmed animals. The federal Humane Slaughter Act applies only to slaughter practices, while the federal Animal Welfare Act explicitly exempts animals on farms. State animal welfare statutes exempt animals raised for food and/or practices that are routine in the industry. While some may call for more humane treatment of the pigs, allowing the pigs to roam on pastures would make animal agriculture even more inefficient, requiring even more resources. Pork and the Environment Animal agriculture is inefficient because it takes so much more resources to grow crops to feed to pigs than it would be to grow crops to feed to people directly. It takes about six pounds of feed to produce a pound of pork. Growing those extra crops requires additional land, fuel, water, fertilizer, pesticides, seeds, labor and other resources. The extra agriculture will also create more pollution, such as pesticide and fertilizer runoff and fuel emissions, not to mention the methane that the animals produce. Captain Paul Watson of Sea Shepherd Conservation Society calls domestic pigs, the world’s largest aquatic predator, because they eat more fish than all the sharks in the world combined. We’re just pulling fish out of the ocean to convert it into fish meal for the raising of livestock, for pigs primarily. Pigs also produce a lot of manure, and factory farms have come up with elaborate systems for storing solid or liquid manure until it can be used as fertilizer. However, these manure pits or lagoons are environmental disasters waiting to happen. Methane sometimes becomes trapped under a layer of foam in a manure pit and explodes. Manure pits can also overflow or can become flooded, polluting the groundwater, streams, lakes and drinking water. Pork and Human Health The benefits of a low-fat, whole foods vegan diet have been proven, including lower incidences of heart disease, cancer and diabetes. The American Dietetic Association supports a vegan diet: It is the position of the American Dietetic Association that appropriately planned vegetarian diets, including total vegetarian or vegan diets, are healthful, nutritionally adequate, and may provide health benefits in the prevention and treatment of certain diseases. Because pigs are now bred to be leaner, pork is not as unhealthy as it once was, but is no health food. Because they are high in saturated fats, the Harvard School of Public Health recommends avoiding red meats, including beef, pork and lamb. Aside from the risks of eating pork, supporting the pork industry means supporting an industry that endangers the public health and not just the health of people who choose to eat pork. Because the pigs are constantly given antibiotics as a preventive measure, the industry fosters the rise and spread of antibiotic-resistant strains of bacteria. Similarly, the pork industry spreads swine flu, or H1N1, because the virus mutates so quickly and spreads quickly among closely-confined animals as well as to farm workers. The environmental issues also mean that pig farms endanger their neighbors health with manure and disease.

Pigs Pork and Animal Rights - What is Wrong with Eating Pork

Pigs Pork and Animal Rights - What is Wrong with Eating Pork Approximately 100 million pigs are killed for food each year in the United States, but some people choose not to eat pork for a variety of reasons, including concerns about animals rights, the welfare of the pigs, the effects on the environment, and their own health. Pigs and Animal Rights A belief in animal rights is a belief that pigs and other sentient beings have a right to be free of human use and exploitation. Breeding, raising, killing and eating a pig violates that pigs right to be free, regardless of how well the pig is treated. While the public is becoming more aware of factory farming and demanding humanely raised and slaughtered meat, animal rights activists believe that there is no such thing as humane slaughter. From an animal rights perspective, the only solution to factory farming is veganism. Pigs and Animal Welfare Those who believe in animal welfare believe that humans can ethically use animals for our own purposes as long as the animals are treated well while they are alive and during slaughter. For factory farmed pigs, there is little argument that the pigs are treated well. Factory farming began in the 1960s, when scientists realized that agriculture was going to have to become much more efficient to feed an exploding human population. Instead of small farms raising pigs outdoors in pastures, larger farms started raising them in extreme confinement, indoors. As the U.S. Environmental Protection Agency explains: There has also been a significant change in how and where hogs are produced in the U.S. over the past 50 years. Low consumer prices, and therefore low producer prices, have resulted in larger, more efficient operations, with many smaller farms no longer able to produce pigs profitably. Pigs are cruelly abused on factory farms from the time they are little piglets. Piglets routinely have their teeth clipped, have their tails cut off and are castrated without anesthesia. After weaning, the piglets are put in crowded pens with slotted floors for the manure to fall through, into a manure pit. In these pens, they each typically have only three square feet of room. When they become too large, they are moved to new pens, also with slotted floors, where they have eight square feet of space. Because of crowding, the spread of disease is a constant problem and the entire herd of animals is given antibiotics as a precaution. When they reach their slaughter weight of 250-275 pounds, at around five to six months of age, most are sent off to slaughter while a small number of females become breeding sows. After being impregnated, sometimes by a boar and sometimes artificially, breeding sows are then confined in gestation stalls that are so tiny, the animals cannot even turn around. Gestation stalls are considered so cruel, they have been banned in several countries and in several U.S. states, but are still legal in most states. When the breeding sows fertility drops off, usually after five or six litters, she is sent off to slaughter. These practices are not only routine but legal. No federal law governs the raising of farmed animals. The federal Humane Slaughter Act applies only to slaughter practices, while the federal Animal Welfare Act explicitly exempts animals on farms. State animal welfare statutes exempt animals raised for food and/or practices that are routine in the industry. While some may call for more humane treatment of the pigs, allowing the pigs to roam on pastures would make animal agriculture even more inefficient, requiring even more resources. Pork and the Environment Animal agriculture is inefficient because it takes so much more resources to grow crops to feed to pigs than it would be to grow crops to feed to people directly. It takes about six pounds of feed to produce a pound of pork. Growing those extra crops requires additional land, fuel, water, fertilizer, pesticides, seeds, labor and other resources. The extra agriculture will also create more pollution, such as pesticide and fertilizer runoff and fuel emissions, not to mention the methane that the animals produce. Captain Paul Watson of Sea Shepherd Conservation Society calls domestic pigs, the world’s largest aquatic predator, because they eat more fish than all the sharks in the world combined. We’re just pulling fish out of the ocean to convert it into fish meal for the raising of livestock, for pigs primarily. Pigs also produce a lot of manure, and factory farms have come up with elaborate systems for storing solid or liquid manure until it can be used as fertilizer. However, these manure pits or lagoons are environmental disasters waiting to happen. Methane sometimes becomes trapped under a layer of foam in a manure pit and explodes. Manure pits can also overflow or can become flooded, polluting the groundwater, streams, lakes and drinking water. Pork and Human Health The benefits of a low-fat, whole foods vegan diet have been proven, including lower incidences of heart disease, cancer and diabetes. The American Dietetic Association supports a vegan diet: It is the position of the American Dietetic Association that appropriately planned vegetarian diets, including total vegetarian or vegan diets, are healthful, nutritionally adequate, and may provide health benefits in the prevention and treatment of certain diseases. Because pigs are now bred to be leaner, pork is not as unhealthy as it once was, but is no health food. Because they are high in saturated fats, the Harvard School of Public Health recommends avoiding red meats, including beef, pork and lamb. Aside from the risks of eating pork, supporting the pork industry means supporting an industry that endangers the public health and not just the health of people who choose to eat pork. Because the pigs are constantly given antibiotics as a preventive measure, the industry fosters the rise and spread of antibiotic-resistant strains of bacteria. Similarly, the pork industry spreads swine flu, or H1N1, because the virus mutates so quickly and spreads quickly among closely-confined animals as well as to farm workers. The environmental issues also mean that pig farms endanger their neighbors health with manure and disease.

Employment Discrimination- Legal research term project Paper

Employment Discrimination- Legal term project - Research Paper Example It is essential to understand the content of employment laws that prohibit discrimination because inadequately following these laws may cost a company vast resources as a result of litigation if that company is not careful to prevent discriminatory practices in its hiring and employment. Employment discrimination is discrimination in the process of hiring, promoting, assigning, terminating, or compensating employees, which includes any kind of harassment or on-the-job persecution.2 Most often, this kind of discrimination is defined in terms of an impact on members of a particular class or category of people, such as ethnicity, gender, or disability. Measuring discrimination relative to the effect on members of protected classes is necessary because without membership in particular classes of people, there would be no basis for people to discriminate or hold prejudices against others. Clearly, discrimination can either occur on an explicit or implicit level, which corresponds to the d ifference between intentional and unintentional discrimination. In the case of unintentional, or implicit, discrimination, there may be subconscious biases or prejudices that a hiring manager may have against people of a certain group (e.g. that physically handicapped people are below average in intelligence) can cause a disparate impact on that group, simply through the manager’s hiring decisions.3 This impact may extend past the hiring process and into the areas of wage discrimination and workplace retaliation for various reasons. There are Constitutional limits on employment discrimination such as the Fifth and Fourteenth Amendments, as well as a number of Federal laws. Although Constitutional dictates are universal, they apply only to employment in government and not in the private workplace. Among the most important pieces of Federal legislation against employment discrimination is Title VII of the Civil Rights Act of 1964, which prohibited discrimination based on race, color, religion, sex or national origin regarding terms, conditions, and privileges of employment. This coincided with the granting of civil rights to minorities in the United States in other areas of public life not expressly dealing with employment. One year prior to the CRA, the Equal Pay Act (EPA) of 1963 banned compensation for employees that differs based solely on sex and not on any other factor relative to the job. While it does not exclude other discriminatory practices in hiring, one of the EPA’s conditions is that workers who perform equal work in jobs requiring â€Å"equal skill, effort, and responsibility and performed under similar working conditions† should be provided equal pay.4 Although the pay differential between the sexes has not evened out completely since 1963, the law has been successful in paring much of the deficit. Employment

Personal Essay Example | Topics and Well Written Essays - 2500 words

Personal - Essay Example Each of the section also contains background information of each type of services offered by the bank. The financial banks offer several services for the customers and each of them has different importance for different types of customers. The introduction of technology and the fast growth of internet usage have allowed the financial companies to add more value to the customers without much effort. The beginning of internet banking has made it easier for the customers to conduct their banking activities at ease and at their convenience. Although the mode of banking has evolvedbut the overall concept of individual activities are still the same. This paper is focused on the services offered by HSBC bank in their website. It will cover three basic services in details, which are Banking, Borrowing and Investing. The Qatar branch of HSBC will also be covered in this paper. Savings Bank Account:The banking segment of HSBC offers two types of services, savings account and current account. An individual can choose anyone or both types of account depending on his requirements. The savings account allows an individual to accumulate funds and gain interest on it. It helps the individual to save money for future use. Current Bank Account: The current bank account is particularly for business purposes and offers services, which are exclusive to financial activities of a business. It allows the customers to deal with liquid funds, such as deposit funds, withdraw funds, write check, etc. Moreover, the customers can make unlimited transactions in a day (Money, 2015). HSBC Qatar offers three different types of accounts based on the requirement of the customers. They are Basic Current Account, Advanced Current Account and Premier Current Account. Money Transfer: The money transfer facility of HSBC Qatar allows the customer to transfer funds to different accounts. The customers can transfer money to pay bills, send money to

The expansion of dough Essay Example for Free

The expansion of dough Essay There are many factors that may have an effect on the expansion of dough but I will research temperature and material, the experiment is as follows. 25g of flour will be weighed into a beaker, and sugar will then be added. 30cm3 of yeast suspension will be measured in the 50cm3 measuring cylinder, and then added to the flour and sugar. It will then be stirred until a smooth paste. The paste will then be poured into the 250cm3 measuring cylinder without touching the sides. This is a precaution, because otherwise there will not be the correct amount of paste. The volume of the paste in the measuring cylinder will be recorded and the cylinder will be placed in one of the waterbaths, the temperature noted. The clock will be started and the volume recorded every 2mins for about 30mins. I think this experiment will work because dough is known to rise when heated I think that the higher the temperature, the bigger the expansion and if left over a period of time, at the same temperature, it will increase further, until a certain point. I believe this, because yeast is made up of a single-celled organism, Saccharomyces cerevisiae, which multiplies rapidly when fed sugar and the yeast will convert starch to glucose, a simple sugar. This ferments the sugar, which converts to alcohol and carbon dioxide. The carbon dioxide gas helps raise the dough and the dough rapidly expands, increasing in volume. To support my hypothesis further I had to research, I found the following sites and books helpful: http://encarta. msn. co. uk/find/Concise. asp? z=1pg=2ti=761556236 http://homecooking. about. com/library/weekly/aa072197b. htm Biology for AQA separate award by Ann Fullick. I have performed the experiment using the method mentioned previously. I have paid attention to the precautions carefully, and tried to do it correctly and as precise as possible and have obtained the following results: Time (mins) Volume (cm3) Temp: 22i C-glass Temp: 32i C-plastic Temp: 32iThe results shown in the table prove that the higher the temperature, the further the dough will rise, supporting my hypothesis. To support my hypothesis further I had to research, I found the following sites and books helpful: http://encarta. msn. co. uk/find/Concise. asp? z=1pg=2ti=761556236 http://homecooking. about. com/library/weekly/aa072197b. htm Biology for AQA separate award by Ann Fullick The graph, on the next page, shows that when dough is heated at a higher temperature it will rise faster. However, if heated in a glass-measuring cylinder, it would have perhaps risen further than it did. This can be seen by comparing the dough at 32i C in the plastic measuring cylinder (A) and the dough at 22i C in the glass-measuring cylinder (B). Although A is 10iC above B for the first fourteen minutes, they are constantly crossing temperatures. As line of best fit, starts lower than B, its intercept being 23 and Bs being 32. From the graph, the differences between the lines can be seen easily, at 37i C, it had risen the most and at 22i C, it had risen the least, the difference between the two being 46 cm3. At 22i C, it raised 28cm3, at 32i C it raised 44cm3, and at 37i C it raised 74cm3, and the graph showed this. From the line of best fit, the lines can be compared by their intercepts and gradients easily. However, the line which each set of results form is more important.Each of them show a steady rise, but the steadiest is the dough at 37i C, this suggest that perhaps this is an ideal temperature for rising dough, not too high as to kill the yeast and not too low, so it wont grow as fast and as steady. This also helps me to understand why a change in material will help the dough rise faster or slower. If in a glass container, the heat can pass through easily, and so it will rise faster, but because plastic is an insulator, the heat cannot pass through as easily. In conclusion, I can form the opinion that dough will expand more rapidly when at a higher temperature, perhaps ranging between 30iand 40i , and in a container that is not heat resistant, and the graph shows this in a simpler form. I think this because yeast multiplies at a faster rate in a high heat, however, if too high, it will die. Also, the graph shows the dough rising at a steady rate at 37i C, and so at 40i C it would perhaps rise faster, and it raises relatively well at 32i C. Although the yeast would probably rise faster in a higher heat, within bread the carbon dioxide gas given off would probably create pockets within the bread, or the yeast would begin to die. The results have turned out as expected, supporting my prediction. My method gave evidence that was reliable, and so would be counted on as correct. I believe this because it showed how yeast can be useful and expands dough in higher temperatures. By producing dough and exposing it to the conditions in which I wanted to test it, I could produce reliable results. This was done by measuring the dough carefully and fairly, using the same ingredients as a precaution, making the investigation fair; and then heating it at a steady temperature. By recording it throughout, I was able to produce a graph, to show my results in a clear and precise way. I think that I have given enough evidence to draw a conclusion. However, I think that this investigation could be advanced, by heating dough at a lower temperature, such as 15i C, in two different materials, and then the same again at a higher temperature, such as 50i C, also at a middle temperature, such as 18i C. By comparing two extremes and an intermediate, we can see if yeast will rise any more rapidly and steadily at the different temperatures and more importantly, if the materials in which they are heated make a difference. This would help support my earlier conclusion, that dough will expand more rapidly when at a higher temperature, perhaps ranging between 30i and 40i , and in a container that is not heat resistant. Investigation to observe the effect of temperature on the expansion of dough Dominique Briggs 10y Biology Mrs Tottey Show preview only The above preview is unformatted text This student written piece of work is one of many that can be found in our GCSE Patterns of Behaviour section.

An Examination of Visual Agnosia Essay -- Term Papers Research

An Examination of Visual Agnosia Imagine a researcher requesting you to copy a picture. It's a simple task. You move your instrument of illustration across a sheet of blank paper with ease, glancing from the given picture to your own sketch in progress. When you are finished you observe a satisfactory replica and feel a sense of accomplishment and proficiency with the similarity you have achieved between picture and sketch. Then the researcher queries whether you can tell him what you have drawn. You search the interconnected lines, the edges, and the shapes of your sketch but cannot answer what the picture represents. Finally, an explanation is given. You have just drawn a house- a simple triangle resting on top of a square. Your sense of accomplishment is quickly replaced with a feeling of despair. Visual agnosia is a neurological disorder characterized by the inability to recognize familiar objects (Farah, 1990). Object recognition is the ability to place an object in a category of meaning. Most cases of visual agnosia are brought about through cerebral vascular accidents or traumatic brain injury typically inhibiting sufficient amounts of oxygen from reaching vital body tissues (Zoltan, 1996). There are a vast array of impaired abilities and deficits associated with individuals diagnosed with visual agnosia. These impairments vary considerably from individual to individual (Farah, 1990). Some patients cannot recognize pictures of things such as trees and birds, despite being able to describe such objects or recognize them through other senses such as sound and touch. Other patients demonstrate an inability to recognize faces of friends and family members (Goodale, 1995). The functional impairments experienced as a r... ...idence. Neuropsychologia, 29, 949-958. Farah, M.J. Relations Among the Agnosias. Case Studies in the Neuropsychology of Vision. The Psychology Press: UK, 1999. (9) 181. Goodale, M.A. (1995) Perceiving the World and Grasping It: Is there a difference? Lancet, 343, 930. Humphreys, G.W. Case Studies in the Neuropsychology of Vision. The Psychology Press: UK, 1999. Sajda P. & Finkle, L.H. (1995) Intermediate Visual Representations and the Construction of Surface Perception. Journal of Cognitive Neuroscience, 7, 267-291. Vecera, S.P. & Gilds, K.S. (1998) What Processing is Impaired in Apperceptive Agnosia: Evidence from Normal Subjects. Journal of Cognitive Neuroscience, 10 (5), p.568 Zoltan, B. Vision, Perception, & Cognition: A Manuel for the Evaluation and Treatment of the Neurologically Impaired Adult. Slack Incorporated: New Jersey, 1996. 109-111.

Types Of Food And Water Contamination Environmental Sciences Essay

About every individual twenty-four hours our universe additions a vegetarian. Most people become a vegetarian out of regard for our animate beings, some because merely dont like meat. First of all, biological meat is better for the environment. The animate beings at biological farms have a better life ; they can travel about freely, acquire outside and eat proper nutrient. Furthermore, biological farms do non utilize fertilisers, chemical supplies or cistron engineering, so the meat you are purchasing is really better for your ain wellness. You can acquire biological meat at whole nutrient and wellness nutrient shops, some farm stores, and biological meatmans and even the better supermarkets. The environment section of the Dutch authorities is back uping supermarkets to acquire biological nutrient and to put up a good run, because biological nutrient is still more expensive in the universe. The taint of nutrient by chemical jeopardies is a world-wide public wellness concern and is a taking cause of trade jobs internationally. Contamination may happen through environmental pollution of the air, H2O and dirt, such as the instance with toxic metals, PCBs and dioxins, or through the knowing usage of assorted chemicals, such as pesticides, carnal drugs and other agrochemicals. Physically taint occurs when objects that get into the nutrient point and this can class taint. 1.1.1 TYPE OF CONTAMINATED BY BIOLOGICAL Food can be contaminated by biological because there are two types of biological agents are pathogens and toxins. Sanitation in fixing and functioning nutrient will cut down taint by pathogens. Toxins are toxicant substances produced by pathogens and other organisation to protect nutrient from toxins, stored it in sealed, air-tight containers so to avoid the taint we must decontaminate the containers before opening them. In handling the job of biological it is assumed that there could be contaminated by personal of all open surfaces, and of go arounding air. The illness could be caused by taint that had occurred several yearss, or hebdomad earlier. In instance of biological onslaught there are certain direction that should for carried out for protection and decontamination of feeding, imbibing, nutrient service equipment and messing countries. The best manner to forestall biological taint is to make good sanitary and hygienic pattern. 1.1.2 TYPE OF CONTAMINATED BY CHEMICALLY Chemical nutrient taint refers to the presence in nutrient harmful chemicals and micro-organism which can do consumer unwellness. The chemical taint of nutrient as microbiological taint is under the nutrient borne unwellness. Largely the chemical taint is modified nutrient, or the nutrient ingredients from genetically modified being besides can organize the nutrient taint. The nutrient borne unwellness can caused by certain cleansing compounds, and sometimes by usage the improper containers ( pots ) for cooking or hive awaying nutrient. Sometimes drug besides are used in agribusiness chemicals to command the infestation of fruit and veggie. When a big sum of chemicals are used it can caused a serious nutrient borne unwellness. The full toxicant chemical and cleaning compound must be carefully stored and labeled and shop in country that separate from the nutrient point. The best manner to forestall chemical nutrient borne unwellness are all the fruit and vegetable must be rinse decent ly so that the chemical will destruct in the H2O. We can even utilize warm H2O or even a hot H2O to rinse it. Examples of toxic metal that can do chemical taint are: Lead: found in pewter, illustration is pitcher and tableware Copper: found in cooking utensil, illustrations are pots and Pons Zinc: found galvanized points, illustrations are pail and bath 1.1.3 TYPE OF CONTAMINATED BY PHYSICALLY There is few type of physical taint that occurs. The first is from human existences. Sometimes the point that can do physical taint are, hair, soil, hurting french friess, buttons, coins, jewelry makers, plaster, and finger nail, go mix with the nutrient. The 2nd is from equipment in the hotel. The equipment that can contamination because from the, glass, metal, wood, plastic, prison guard, nuts, and bolts. The 3rd are largely from nutrient point are delivered in some sort of packaging or containers. If the packaging is damaged, or non to the full removed it may go a beginning of physical taint. Example the point are, polythene, paper, composition board, plastic or even glass. The 4th type of taint are from the unwanted parts of natural ingredients that remain in nutrient after readying including illustration, egg shell, castanetss, pips, chaffs, dirt or grit. The last physical taint are from the spread disease, they besides can do physical taint because the contaminated from the, de ad insect organic structures, larvae or eggs, dungs of pelt or a bird plume. To avoid the taint we must manage the nutrient point with carefully. 1.2 DEFINATION OF PORTABLE WATER ( The above beginnings from www.portable water.com ) Portable H2O is a safe H2O to be drink by all human existences or besides animate beings. Water may be of course drinkable, as is the instance with pristine springs, or it may necessitate to be treated in order to be safe. In either case, the safety of H2O is assessed with trials which look for potentially harmful contaminations. Largely portable H2O is packaged in plastic, or glass. It is a merely H2O that s safe to be drink by all. Water which is contaminated can treated to turn into portable H2O. Once of the easiest W P treat the H2O is boiling. Boiling H2O may non take heavy taints, but it can neutralize most bacteriums and viruses which may show H2O can besides treated with chemicals such as bleach, which sometimes it signifier of tablets for field and encampment usage. In extra, H2O can be pumped through a filter to take particulate. 1.3 PORTABLE WATER USED FOR: 1.3.1 PORTABLE WATER STORAGE TANKS ( The above beginnings from www.portable H2O tanks.com ) Portable H2O storage armored combat vehicles can be used in a figure of applications. If there is a break in the lasting H2O supply a portable armored combat vehicle can be used as a impermanent solution. They can be used as firefighting equipment, typically in distant locations or for forest fires. They can besides be used in distant locations where a work cantonment needs to be set up for a period of clip. There are many different utilizations for them and they can be an effectual piece of equipment 1.3.2 WATER PURIFIER ( The above beginnings from www.water purifier.com ) Most H2O we would believe of as clean contains a assortment of different contaminations, including chemical and biological contaminations. Chemical contaminations are chemicals that have entered the H2O. We can kill biological contaminations in the H2O by boiling it, but unluckily, boiling H2O has no consequence on chemicals already in the H2O. However, utilizing a H2O purifier can take both biological and chemical contaminations at the same clip, ensuing in H2O that is clean and safe to be drink by household. 1.3.3 PORTABLE WATER BOTTLE ( The above beginnings from www.portable H2O bottle.com ) The portable H2O bottles are a new sort of filtered H2O bottle. If you one to make at out of place we can merely used the portable H2O bottle. With this filtered H2O bottle you can merely even travel anyplace without any job. The portable H2O bottle, it can cut down 99.99 % of contaminations such as cryptosporidium, Giardia, E-coli, and many more. The bottle is design for going, exerting, athleticss events, and catastrophes or even can be used at place. The H2O bottle is really save and the H2O besides is safe to be drink. 1.3.4 PORTABLE WATER HEATER: ( The above beginnings from www.portable H2O heater.com ) Water warming is a thermodynamic temperature procedure utilizing a warming beginning to heat H2O above its initial temperature. Portable H2O is normally heated by device known as a H2O warmer or hot H2O system. Water warmer for non portable usage, both industrial and domestic are besides called hot H2O boilers. When a shell and tubing heat money changer is used for portable H2O or non portable H2O warming, it is normally called a hot H2O generator.

Lady Gaga: Gender in “Love Game”

Justine Burke Professor Adigweme Rhetoric 10:03:145 9/24/10 Lady Gaga: Gender in â€Å"Love Game† Many artists today are always trying to be somebody they are not. Their costumes are getting bigger and crazier than ever. One artist that exceptionally stands out in the crowd of performing artists is Lady Gaga. Every costume she wears, every move she makes becomes more epic every time she is seen. Most of the costumes she wears hide her identity and it is unknown who she is really trying to be.In â€Å"Love Game,† Lady Gaga’s gender is being questioned by the lyrics and image of the frame, by the subjectiveness in the video, by tweaking others’ work into hers, how the clothing and lighting give symbols to her gender, and who she is ultimately trying to be. Gender is a huge question in the text of this song. According to the lyrics and image of this frame, Lady Gaga is playing her love game with her candidates. They are in a dirty subway station with the ligh ts of two trains behind them illuminating the frame.Gaga is clearly the center of attention where everyone wants to win her over. She wants to know if the â€Å"subject† who could be male or female, will actually like her for her, or if the subject just wants the fame. When it is said â€Å"Let’s have some fun, this beat is sick,† the energized dancing and the careless crotch grabbing in the choreography shows that Lady Gaga and her subjects are simply having fun dancing to the beat.With the words â€Å"I wanna take a ride on your disco stick,† would normatively be seen as a woman’s line, but if Lady Gaga is playing the gender game in her video, like she is in the middle of the video by kissing both a male and a female, then she could ultimately be a male speaking that line to another male. Gaga indicates her subject to be a male with the line â€Å"guess he wants to play. † She doesn’t want to get too emotionally close with this man because she’s still not sure if he’s going for her love or with her game of touching and kissing and sex for the fame. No matter what Gaga’s subjects are searching for, whether it is love or fame, they are dancing very subjective towards her. They all want to win her over as she is letting them dance on and around her anyway they want. The men are suggestive towards her by grinding on her, giving her suggestive looks, and by chasing her. Lady Gaga shows this by wearing very little clothing, twirling her hair around, and letting the men dance and grind on her. A lot of the main choreography symbolizes Michael Jackson’s work. * Lady Gaga seems to symbolize others’ work a lot.Such as Grace Jones’ work. Grace Jones is a model, actress, and a singer/performing artist. When comparing the outfits she used to wear to the outfits Lady Gaga wears today, she clearly seems to be copying Grace Jones. Jones said, â€Å"I’ve seen some things sheâ⠂¬â„¢s worn that I’ve worn, and that does kind of piss me off. † (Hattenstone). Lady Gaga also follows in the footsteps and appears to be copying actresses such as: Brigette Helm, Beyonce, and Madonna by wearing an outfit that symbolizes the Maschinenmensch in her video â€Å"Telephone. * Even though Gaga is always being accused of copying others’ work we have to respect her for what she does as music lovers. Lady Gaga is not copying older artists, she is being unique, tweaking great ideas that have not been touched in years, putting her swag on them, and making old idea’s into new and improved ideas. Lady Gaga says, â€Å"I eat, sleep, breathe, and bleed every inch of my work† (Vicks). This is clearly what Gaga does and proves that she loves every aspect of what she does and that is the kind of dedication one must have in order to be a performing artist.She clearly could not be working any harder at this point in her life as she is continuously ma king number one hits such as: â€Å"Alejandro,† â€Å"Love Game,† â€Å"Bad Romance,† â€Å"Paparazzi,† â€Å"Poker Face,† and â€Å"Telephone. † * One aspect in her hit â€Å"Love Game,† in this frame Lady Gaga is wearing a different color top than everyone around her and is in the center of the formation. This indicates from the text that it is her game and everyone else wants to win her over hoping to play the game with her. All of her performers are wearing dark clothes though.This indicates dirtiness and impurity. Another costume effect is that one of Gaga’s dancers and herself are wearing a small symbol of an SS Soldier uniform within their outfits. Often in video’s, performers act to be someone they are not. They personally do not have any connections with the Nazi’s, but they are indicating and symbolizing that they are trying to be someone they are not. For instance, Lady Gaga makes us question her gender in this video. Not knowing this information shows that her gender s unknown. * If something is unknown it is put in the dark, like a mystery. The low lighting in the frame symbolizes the mystery of Lady Gaga’s gender and who she is trying to be in this video. The darkness also symbolizes the dirty and impure subway. Now that it is the end of the video and she has been through the subway she is impure and the darkness symbolizes this. These men are druggie type of men whom are stereotypically looking for specific things, like women and drugs, all for their pleasure.There are many different types of subjects in the world and this is where Gaga chooses to look for her subject. The light that is shining through is simply used to illuminate the dancers. Or, it also symbolizes more trains coming for the game to start all over again. * Subways are dark places at night and there can be isolated groups of people in them. Lady Gaga and her subjects are the only ones at the subway stat ion and there is no one else around, like their own little group. This is a perfect opportunity for Gaga to choose her sexuality and the person she wants all to herself.Since there are so many different types of subjects and groups of people found at a subway station, Gaga could ultimately choose to be just like one of those people she may see. She can be whoever she wants. She chooses to be a male with the dance move she is performing. * There are so many different kinds of people in the world, especially in one of the biggest cities in America, New York City. This is where many subway stations are located that people hear about and have never used that aren’t from NYC.There are any type of persons and groups there such as: male, female, straight, queer, bisexual, performer, dancer, gang member, business man, student, etc. There are many different things in life that can veer someone to become any person they want to be and to choose their identity by. The norm at a place li ke this is to be different, unlike in a smaller city. It is a perfect place for the film to be shot. Even if this video was not shot in New York City, it still represents a place like it and all the identities that are found there.This is where the ultimate question falls. Who is Lady Gaga trying to be and who is she supposed to be? * Lady Gaga’s gender in this frame at the end of the video has turned into an impure male symbol. This identity is becoming more of a norm in society today, that is, homosexuality. This is what she is representing. Gaga is trying to make what isn’t normal in society, what isn’t safe, what isn’t in people’s comfort zone, what is completely outside of the box, and wants to make it the norm. She wants to make it all okay things to be and she is the one doing it.With this said Lady Gaga is one of the main artists that definitely stands out in the crowd. This makes her be able to do whatever she wants and not care how much s he gets judged. There was uncertainty about her identity in â€Å"Love Game,† but now it is analyzed who she is. * * * * * * * * *Works Cited * Hattenstone, Simon â€Å"Grace Jones: ‘God I’m scary. I’m scaring myself’† The Guardian (2010) * Vicks, Meghan â€Å"The Icon and the Monster: Lady Gaga is a Trickster of American Pop Culture† Gaga Stigma: Critical Writings and Art About Lady Gaga (2010)

Augustus and the Augustan Age of the Roman Empire

Augustus and the Augustan Age of the Roman Empire During the Viet Nam War, the U.S. witnessed how little it means for Congress to have the power to declare war when the Commander-in-Chief of the Armed Forces, and the President, can order troops to engage in police actions. In recent decades weve watched military dictatorships the world over wreaking havoc on civilians in the name of the martial law. And in Imperial Rome, the praetorian guard installed Claudius as the first of the militarily-elected emperors. Having power over the militia means having the power to ignore the will of the people. This was as true with Augustus as it is today. To the extent that Augustus didnt abuse his powers, he was a good leader, but his consolidation of not only military power but also the tribunitian and proconsular in the hands of one man set the stage for the end of popular freedom. The Roman historian Tacitus, from the early imperial period (A.D. 56?-112?), enumerates the powers Augustus swallowed: [Augustus] seduced the army with bonuses, and his cheap food policy was successful bait for civilians. Indeed, he attracted everybodys good will by the enjoyable gift of peace. Then he gradually pushed ahead and absorbed the functions of the senate, the officials, and even the law. Opposition did not exist. War or judicial murder had disposed of all men of spirit. Upper-class survivors found that slavish obedience was the way to succeed, both politically and financially. They had profited from the revolution, and so now they liked the security of the existing arrangement better than the dangerous uncertainties of the old rà ©gime. Besides, the new order was popular in the provinces. (1. 2) From The Annals of Tacitus The peace Tacitus refers to is peace from civil war. The bait evolved into what the satirist Juvenal later describes as panem et circenses bread and circuses. The other actions led to the fall of Romes form of republican government and the rise of the single head of Rome, the princeps or emperor. Vice Like leaders today, Augustus sought to end vice. Definitions then were different, though. Three of the problems he faced were: extravagance, adultery, and declining birth rates among the upper classes. Previously, morality had been an individual or family matter. Augustus wanted it to be a matter for legislation, complete with tax incentives for those who married and had children. The Romans didnt want to change their behavior. There was resistance, but in A.D. 9, the law now referred to as lex Julia et Papia passed. Powers originally delegated the pater familias were now matters for the princeps Augustus. Where earlier a husband was justified in killing a man he found in bed with his wife, now it was a matter for the courts. Lest this seem humane and evidence of concern for the rights of individuals, the father of the woman caught in adultery was still allowed to kill the adulterers. [See Adulterium.] Augustan Age Sources The Oxford History of the Classical World, edited by Oswyn Murray, John Boardman, and Jasper GriffinA History of the Ancient World by Chester StarrBiography of Horace and selected Odes in translationLegal Status In The Roman WorldThe Ancient History Bulletin 8.3 (1994) 86-98 Leges sine moribus, by Susan Treggiari.Horatian Meters Augustus was impartial in his harsh judgments. When his daughter, Julia, his child by Scribonia, was caught in adultery, she suffered the same fate as any other daughter exile [See Dio 55.10.12-16; Suet. Aug. 65.1, Tib. 11.4; Tac. Ann. 1.53.1; Vell. Pat. 2.100.2-5.]. Literature Augustus was restrained in his personal use of power. He tried not to force people to do his will and left at least the appearance of choice: Augustus wanted an  epic poem  written about his life. While its true that he eventually got one, he didnt punish those in his literary circle who turned him down. Augustus and his colleague, the wealthy  Etruscan  Maecenas  (70 B.C.- A.D. 8), encouraged and supported members of the circle, including  Propertius,  Horace, and  Vergil. Propertius didnt need the financial input, but more than that, he wasnt interested in writing epic. His shallow apology to Augustus was on the order of I would if I could. Horace, son of a freedman, needed the patronage. Maecenas gave him a Sabine farm so he could work at leisure. At last, as unencumbered by poverty as he was now burdened by obligations, Horace wrote the and Epodes Book 4 to glorify the emperor. The  Carmen Saeculare  was a festival hymn composed to be performed at the  ludià ‚  saeculares  (secular games). Vergil, who likewise received remuneration, kept promising to write the epic. He died, however, before finishing  The Aeneid, which is considered an ambitious attempt to join the legendary history of Rome with the glorious and noble present embodied in Emperor  Augustus. [See Horace and Augustus, by Chester G. Starr.  The American Journal of Philology, Vol. 90, No. 1 (Jan. 1969), pp. 58-64.] Tibullus and  Ovid, two later writers in Augustus literary circle, were under the patronage of Messalla, rather than Maecenas. Independently wealthy, highly successful Ovid, who was considered the embodiment of Augustan poetry, mocked everything. He was irreverent towards the new morality, even going so far as to write what could be viewed as guidebooks to adultery.  Eventually, he went too far and was exiled by Augustus to Tomi where Ovid spent the rest of his life pleading for recall. [See  DIR Augustus.] A Hard Act To Follow Augustus, living under the shadow of his adoptive fathers assassination, was aware that the appearance of dictatorship could spell his doom. As he amassed power, Augustus took care to make it look constitutional, but all the while, power was accruing in the hands of one man rich, popular, smart, and long-lived.  He  was a hard act to follow and with the reduction of power in the Senate and people, the time was ripe for autocracy. The two passages quoted on the preceding page, the Asian Decree, which calls Augustus the bringer of overwhelming benefaction and Tacitus evaluation of him as a man who used bribes, judicial murder, and absorbed the functions of the senate, the officials, and even the law, could hardly be more different, yet they equally reflect near contemporary attitudes towards Augustus.

How Mild Intellectual Disability Is Defined

How Mild Intellectual Disability Is Defined Editors note: Since this article was originally written, mental retardation as a diagnosis has been replaced with an intellectual or cognitive disability.   Since the term retard made its way into the lexicon of the schoolyard bully, retardation has also become offensive. Retardation did remain as part of the diagnostic vocabulary until the publication of the DSM V. What Is Mild Intellectual Disability (MID), Also Referred to as Mild Mental Retardation? Many of the characteristics of MID correspond to those of Learning Disabilities. The intellectual development will be slow, however, MID students have the potential to learn within the regular classroom given appropriate modifications and/or accommodations. Some MID students will require greater support and/or withdrawal than others will. MID students, like all students, demonstrate their own strengths and weaknesses. Depending on the educational jurisdiction, criteria for MID will often state that the child is functioning approximately 2-4 years behind or 2-3 standard deviations below the norm or have an IQ under 70-75. An intellectual disability may vary from mild to profound. How Are MID Students Identified? Depending on the education jurisdiction, testing for MID will vary. Generally, a combination of assessment methods is used to identify mild intellectual disabilities. Methods may or may not include IQ scores or percentiles, adaptive skills cognitive tests in various areas, skills-based assessments, and levels of academic achievement. Some jurisdictions will not use the term MID but will use mild mental retardation. (see note above.) Academic Implications of MID Students with MID may demonstrate some, all or a combination of the following characteristics: 2 to 4 years behind in cognitive development which could include math, language, short attention spans, memory difficulties and delays in speech development.Social relationships are often impacted. The MID child may exhibit behavior problems, be immature, display some obsessive/compulsive behaviors and lack the understanding of verbal/nonverbal clues and will often have difficulty following rules and routines.Adaptive skills, everyday skills for functioning, may be compromised. These children may be clumsy, use simple language with short sentences, have minimal organization skills and will need reminders about hygiene, such as washing hands, brushing teeth (life skills). etc.Weak confidence is often demonstrated by MID students. These students are easily frustrated and require opportunities to improve self-esteem. Lots of support will be needed to ensure they try new things and take risks in learning.Concrete to abstract thought is often missing or significantly delayed. This include s the lacking ability to understand the difference between figurative and literal language. Best Practices Use simple, short, uncomplicated sentences to ensure maximum understanding. Repeat instructions or directions frequently and ask the student if further clarification is necessary.Keep distractions and transitions to a minimum.Teach specific skills whenever necessary.Provide an encouraging, supportive learning environment that will capitalize on student success and self-esteem.Use appropriate program interventions in all areas where necessary to maximize success.Use alternative instructional strategies and alternative assessment methods.Help the MID student develop appropriate  social skills to support friend and peer relationships.Teach organizational skills.Use behavior contracts, and reinforce positive behavior if necessary.Ensure that your routines and rules are consistent. Keep conversations as normal as possible to maximize inclusion with peers. Teach the difference between literal/figurative language.Be patient! Assist with coping strategies.

Measure understand and knowing of cloud computing services Essay

Measure understand and knowing of cloud computing services - Essay Example It also makes the routine computation works, far easier so, undoubtedly cloud computing can be a constructive support for organizations. This report will discuss in detail about the basic concepts of cloud computing, different types of cloud computing services, cloud computing service providers, advantages and disadvantages of cloud computing. Cloud computing is an internet based computing technology that involves a large number of collective resources. The term ‘cloud’ refers to the internet. Instead of relying on a single personal computer or a local server for their applications like data processing, storage, and others, organizations can make use of the cloud computing services that involves a number of remote servers for this purpose (Beal, n. d.). Also applications can be accomplished more efficiently using cloud computing rather than using conventional personal devices (Gordon and Marchesini, 2010).The purpose of cloud computing is to have abundant and easier access to the internet so that, retrieval and working on data is possible from anywhere across the world (Gordon and Marchesini, 2010).The services offered by cloud computing service providers can be broadly classified into three categories. They are software as a service (SaaS), platform as a service (Paas), and Infrastructure as a service (Iaas) . Let us see in detail about all the above mentioned types with real examples for each type. Software as a service (SaaS) render web services to the clients who access the applications that are accomplished by third party vendors through the interface provided by them. Special installations or downloads are not required for this purpose and applications can be run using the web browsers directly (â€Å"Understanding the cloud,† 2013). SaaS exhibits certain characteristics which are discussed further. SaaS offer access to commercial software through the web.